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  张志君

  副研究员、硕士生导师。2008年获中科院上海分院神经科学研究所博士学位，2009-2012年期间分别在在美国加州大学旧金山分校和美国马萨诸塞大学医学院接受博士后训练。主要从事星形胶质细胞在脑血管疾病中作用的研究。迄今为止，先后获得国自然、上海市科委、教育部、上海交大等多项基金支持，并在国外重要学术期刊Nature cell biology、Molecular cell、Science、Neuron、PNAS发表多篇重要学术论文，已被引用7000多次。

博士 2003.9-2008.1    突触发育和可塑性研究组，中国科学院神经科学研究所

硕士1999.9-2002.7    解剖学系，中南大学湘雅医学院

学士 1993.9-1998.7    临床医学系，新乡医学院

2016/1 - 至今，    yl6809永利官网，副研究员

2008/9 - 2015/12，  yl6809永利官网，助理研究员

2002/7 - 2003/9，  中科院神经科学研究所，突触发育与可塑性实验室， 研究助理

主要研究领域是胶质细胞在脑血管疾病中的作用以及神经元、胶质细胞、和血管之间的相互作用机制。

1．国家自然科学基金面上基金  项目主持 55万; 起止时间 1/1/2020 – 12/31/2023

2．国家自然科学基金面上基金  项目主持 54万; 起止时间 1/1/2018 – 12/31/2021

3．上海市科技创新面上基金   项目主持 54万; 起止时间 7/1/2018 – 6/30/2021

4．国家自然科学基金青年基金  项目主持 20万; 起止时间 1/1/2008 – 12/31/2011

5．yl6809永利官网医工交叉基金   项目主持 8万; 起止时间 2010 – 2012

1. Wang J, Lin X, Mu Z, Shen F, Zhang L, Xie Q, Tang Y, Wang Y, Zhang Z* and Yang GY*. Rapamycin Increases Collateral Circulation in Rodent Brain after Focal Ischemia as detected by Multiple Modality Dynamic Imaging. Theranostics. 2019; 9(17): 4923–4934. doi: 10.7150/thno.32676.(*co-corresponding author)

2. Song Y, Li Z, He T, Qu M, Jiang L, Li W, Shi X, Pan J, Zhang L, Wang Y, Zhang Z*, Tang Y,  and Yang GY. M2 microglia-derived exosomes protect the mouse brain from ischemia-reperfusion injury via exosomal miR-124.Theranostics. 2019; 9(10): 2910–2923.doi: 10.7150/thno.30879.(*co-corresponding author)

3. Li Z, Gu Y, Wen R, Shen F, Tian HL, Yang GY, Zhang Z. Lysosome exocytosis is involved in astrocyte ATP release after oxidative stress induced by H2O2. Neurosci Lett. 2019 Jul 13;705:251-258. doi: 10.1016/j.neulet.2019.03.046.

4. Zhou PT, Wang LP, Qu MJ, Shen H, Zheng HR, Deng LD, Ma YY, Wang YY, Wang YT, Tang YH, Tian HL, Zhang ZJ*, Yang GY. Dl-3-N-butylphthalide promotes angiogenesis and upregulates sonic hedgehog expression after cerebral ischemia in rats. CNS Neurosci Ther. 2019 Jun;25(6):748-758. doi: 10.1111/cns.13104. (*co-corresponding author)

5. Wang L, Zhou P, Mu Z, Lin X, Jiang L, Cheng Z, Luo L, Xu Z, Geng J, Wang Y, Zhang Z*, Yang GY. Dynamic Detection of Thrombolysis in Embolic Stroke Rats by Synchrotron Radiation Angiography. Transl Stroke Res. 2019 Jan 24. doi: 10.1007/s12975-019-0687-6.(*co-corresponding author)

6. Cai H, Ma Y, Jiang L, Mu Z, Jiang Z, Chen X, Wang Y, Yang GY, Zhang Z. Hypoxia Response Element-Regulated MMP-9 Promotes Neurological Recovery via Glial Scar Degradation and Angiogenesis in Delayed Stroke.  Mol Ther. 2017;25(6):1448-1459

7. Lu H, Song X, Wang F, Wang G, Wu Y, Wang Q, Wang Y, Yang GY, Zhang Z. Hyperexpressed Netrin-1 Promoted Neural Stem Cells Migration in Mice after Focal Cerebral Ischemia.Front Cell Neurosci. 2016;10:223.

8. He X, Lu Y, Lin X, Jiang L, Tang Y, Tang G, Chen X, Zhang Z, Wang Y, Yang GY. Optical inhibition of striatal neurons promotes focal neurogenesis and neurobehavioral recovery in mice after middle cerebral artery occlusion. J Cereb Blood Flow Metab.  2017 ;37(3):837-847.

9. Biswas MH, Almeida S, Lopez-Gonzalez R, Mao W, Zhang Z, Karydas A, Geschwind MD, Biernat J, Mandelkow EM, Futai K, Miller BL, Gao FB. MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations. Stem Cell Reports. 2016;7(3):316-24.

10. Silva MC, Cheng C, Mair W, Almeida S, Fong H, Biswas MH, Zhang Z, Huang Y, Temple S, Coppola G, Geschwind DH, Karydas A, Miller BL, Kosik KS, Gao FB, Steen JA, Haggarty SJ. Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability. Stem Cell Reports. 2016;7(3):325-40.

5. Ma Y, Li Y, Jiang L, Wang L, Jiang Z, Wang Y, Zhang Z*, Yang GY*. Macrophage depletion reduced brain injury following middle cerebral artery occlusion in mice. J Neuroinflammation. 2016;13:38. (*co-corresponding author)

6. Cai H, Mu Z, Jiang Z, Wang Y, Yang GY, Zhang Z. Hypoxia-controlled matrix metalloproteinase-9 hyperexpression promotes behavioral recovery after ischemia. Neurosci Bull. 2015;31(5):550-60.

7. Cai H, Zhang Z, Yang GY. Preconditioned stem cells: a promising strategy for cell-based ischemic stroke therapy. Curr Drug Targets. 2014;15(8):771-9.

8. Liu Y, Tang G, Zhang Z, Wang Y, Yang GY.Metformin promotes focal angiogenesis and neurogenesis in mice following middle cerebral artery occlusion.Neurosci Lett. 2014;579:46-51. 

9. Tang G, Liu Y, Zhang Z, Lu Y, Wang Y, Huang J, Li Y, Chen X, Gu X, Wang Y, Yang GY.Mesenchymal stem cells maintain blood-brain barrier integrity by inhibiting aquaporin-4 upregulation after cerebral ischemia.Stem Cells. 2014;32(12):3150-62.

10. Liu Y, Tang G, Li Y, Wang Y, Chen X, Gu X, Zhang Z, Wang Y, Yang GY.Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion. J Neuroinflammation. 2014;11:177.

11. Chen C, Lin X, Wang J, Tang G, Mu Z, Chen X, Xu J, Wang Y, Zhang Z*, Yang  GY*. Effect of HMGB1 on the paracrine action of EPC promotes post-ischemic neovascularization in mice. Stem Cells. 2014;32(10):2679-89.  (*co-corresponding author)

12. Zhang Z, Almeida S, Lu Y, Nishimura AL, Peng L, Sun D, Wu B, Karydas AM, Tartaglia MC, Fong JC, Miller BL, Farese RV Jr, Moore MJ, Shaw CE, Gao FB.

  Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations. PLoS One. 2013 ;8(10):e76055.

13. Lu Y*, Zhang Z*, Sun D, Sweeney ST, Gao FB. Syntaxin 13, a genetic modifier of mutant CHMP2B in frontotemporal dementia, is required for autophagosome maturation. Mol Cell. 2013;52(2):264-71. (*co-first author)

14. Almeida S, Zhang Z, Coppola G, Mao W, Futai K, Karydas A, Geschwind MD, Tartaglia MC, Gao F, Gianni D, Sena-Esteves M, Geschwind DH, Miller BL, Farese RV Jr, Gao FB. Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects. Cell Rep. 2012;2(4):789-98.

15. Chen G, Zhang Z, Wei Z, Cheng Q, Li X, Li W, Duan S, Gu X. Lysosomal Exocytosis in Schwann Cells Contributes to Axon Remyelination. Glia 2012; 60:295–305

16. Yongjie Ma, Zhijun Zhang, Xiaoliang Wang, Weiliang Xia, Hongchen Gu. Insights into the mechanism of magnetofection using MNPs-PEI/pDNA/free PEI magnetofectins Int J Pharm. 2011;419(1-2):247-54

17. Tong X，Li X, Zhou B, Shen W, Zhang Z, Xu T, Duan S. Ca2+ signaling evoked by activation of Na+ channels and Na+ /Ca2+ exchangers is required for GABA-induced NG2 cell migration. Journal of Cell Biology 2009;186: 113-128

18. Zhang Z*, Chen G*, Zhou W*, Song A, Xu T, Luo Q, Wang W, Gu XS, Duan S. Regulated ATP release from astrocytes through lysosome exocytosis. Nat Cell Biol. 2007, 9:945-953

    19. Luo C, Jiang J, Zhou Q, Zhu X, Wang W, Zhang Z, Han X, Zhu D. Voluntary   exercise-induced neurogenesis in the postischemic dentate gyrus is associated with spatial memory recovery from stroke. Journal of Neuroscience Research 2007;85:1637-1646 

   20. Ge W*., Yang X*., Zhang Z., Wang H., Deng Q., Duan S. Long-Term Potentiation of Neuron-Glia Synapses Mediated by Ca2+-Permeable AMPA Receptors. Science, 2006;312, 1533-1537

   21. Shen W*., Wu B*., Zhang Z., Dou Y., Rao Z., Chen Y., Duan S. Activity-induced rapid synaptic maturation mediated by presynaptic cdc42 signaling. Neuron, 2006;50: 401-414 

   22. Yang Y*., Ge W*., Chen Y., Zhang Z., Shen w., Wu C., Poo M., and Duan S. Contribution of astrocytes to hippocampal long-term potentiation through release of D-serine. PNAS, 2003;100: 15194 – 15199